The Library
The Ultimate On-line Candida Resource
Glossary    Contact Us
 
   
Browse by Category
Your Are Here >> Library Home > Candida In The Body > Immune System > Macrophages > Role of extracellular signal-regulated protein kinase cascade in macrophage killing of Candida albicans

Back

We'd love to hear from you - the Candida Library is for you. Let us know if you have any suggestions, ideas or feedback. Click here to email us.

Role of extracellular signal-regulated protein kinase cascade in macrophage killing of Candida albicans

Role of extracellular signal-regulated protein kinase cascade in macrophage killing of Candida albicans
Stella Ibata-Ombetta, Thierry Jouault, Pierre-André Trinel and Daniel Poulain
Journal of Leukocyte Biology. 2001;70:149-154.

Abstract

The pathogenic yeast Candida albicans and its derived molecules stimulate a wide range of macrophage secretory functions and may adapt to escape being killed by this phagocyte. In this study, phagocytosis of C. albicans and of the
nonpathogenic yeast Saccharomyces cerevisiae was shown to be associated with phosphorylation of the mitogen-activated protein kinase (MAPK)/extracellularly regulated kinase (ERK) pathway in the absence of significant activation of either
p38MAPK or stress-activated protein kinase/c-Jun N-terminal kinase. However, although 80% of endocytosed C. albicans survived after 1 h, 80% of S. cerevisiae cells were killed. Considerable quantitative differences were observed between the two species in the sequential phosphorylation of MAPK/ERK kinase (MEK), extracellularly regulated kinase- 1, and 90-kDa-ribosomal S6 kinases. A lower level of activation of the pathway by C. albicans was associated with a species-specific overexpression of the MEK phosphatase MAPK phosphatase (MKP)-1. Killing of both C. albicans and S. cerevisiae could be reduced using PD98059, which mimics MKP-1 and inhibits MEK phosphorylation, suggesting that specific MKP-1 activation by C. albicans could contribute to its ability to escape the yeast lytic potential of macrophages.

Abstract from:

http://www.jleukbio.org/content/70/1/149.abstract


Keywords: MAP kinases phagocytosis yeast pathogenicity macrophages Role of extracellular signal-regulated protein kinase cascade in macrophage killing of Candida albicans

Rate This Article:

Related Articles

Influence of fluoroquinolones on phagocytosis and killing of Candida albicans
Influence of fluoroquinolones on phagocytosis and killing...

Inhibition of Candida albicans extracellular enzyme activity by selected natural substances
Inhibition of Candida albicans extracellular enzyme...

Life and Death in a Macrophage: Role of Glyoxylate Cycle in Virulence
Life and Death in a Macrophage: Role of Glyoxylate Cycle...