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How long does it take for Candida to spread in the body?

Research studies show that depending on the individual and certain environmental factors, it can take anywhere from a few hours up to 59 hours for fungal candida to go systemic after a person has taken antibiotics.
 

“Oral-intragastric inoculation of 5-6-day-old mice with yeast of a virulent strain of Candida albicans (CA30) resulted in systemic spread within 30 min after challenge. Histological examinations of the gastrointestinal (GI) tract have shown that the highest frequency of invasion of the mucosa by yeast cells occurred in the region of the jejunum 1-3 h after inoculation. Results of ultrastructural examinations of sites where the fungus invaded the bowel wall suggested that C. albicans yeast cells are capable of progressive extracellular digestion of the intestinal mucus barrier and microvillus layer, followed by intracellular invasion of columnar epithelial cells.”

Morphological aspects of gastrointestinal tract invasion by Candida albicans in the infant mouse.

J Med Vet Mycol. 1988 Jun;26(3):173-85.

http://www.ncbi.nlm.nih.gov/pubmed/3050009

 

“The pseudomycelium was found to invade animal epithelia at an average rate of 2 microns per hour, penetrating the entire epithelial thickness during 24-48 h. These data have been extrapolated to clinical pathology. On the basis of experimental data and by measuring the epithelial thickness in some human mucous membranes, the presumable periods of total epithelial penetration were calculated which may lead to vascular invasion and create the danger of dissemination. For different human mucous membranes these periods ranged from 22 to 59 h.”

Velocity of Candida albicans invasion into host tissues.

Mycoses ; 34:293-6.

http://www.ophsource.org/periodicals/ophtha/medline/record/MDLN.1803229

 

“Critical times in the development of infections in optimally challenged BALB/c mice were at 5-10 h (bloodstream fully cleared of fungi), 24 h (start of exponential fungal growth in kidneys) and 48 h (50% of blood cultures become positive.”

Temporal events in the intravenous challenge model for experimental Candida albicans infections in female mice.

Mycoses. 2005 May;48(3):151-61.

http://www.ncbi.nlm.nih.gov/pubmed/15842329


Keywords: how long does it take for Candida to spread antibiotic exposure systemic fungal Candida infection time period range beginner

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