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Melaleuca alternifolia (tea tree) oil inhibits germ tube formation

Melaleuca alternifolia (tea tree) oil inhibits germ tube formation by Candida Albicans

K. A. Hammel;  C. F. Carson; T. V. Riley

"The effect of tea tree oil (TTO) on the formation of germ tubes by Candida albicans was examined. Two isolates were tested for germ tube formation (GTF) in the presence of TTO concentrations (%v/v) ranging from 025%(1/2 minimum inhibitory concentration [MIC]) to 0004% (1/128 MIC). GTF at 4 h in the presence of 0004 and 0008% (both isolates) and 0016% (one isolate) TTO did not differ significantly (P>005) from controls. At all other concentrations at 4 h, GTF differed significantly from controls (P<001). A further eight isolates were tested for GTF in the presence of 0031% TTO, and at 4 h the mean GTF for all 10 isolates ranged 100-685%. Two isolates were examined for their ability to form germ tubes after 1 h of pre-exposure to several concentrations of TTO, prior to induction of germ tubes in horse serum. Cells pre-exposed to 0125 and 025%TTO formed significantly fewer germ tubes than control cells at 1 h (P<005), but only those cells pre-exposed to 025% differed significantly from control cells at later time points (P<001). GTF by C. albicans is affected by the presence of, or pre-exposure to, sub-inhibitory concentrations of TTO. This may have therapeutic implications. "

Full Article:
http://www.informaworld.com/smpp/content~db=all~content=a714030963?words=candida*|albicans




Keywords: Antifungal Candida Melaleuca Tea Tree candida albicans

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