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Enhanced phagocytosis and intracellular killing of Candida Albicans

Enhanced phagocytosis and intracellular killing of Candida albicans by GM-CSF-activated human neutrophils 

 

M.D. Richardson;  C.E.D. Brownlie; G.S. Shankland

 

"Little is known about effector cell modulation regarding phagocytosis and candidacidal activities of human neutrophils in response to granulocyte-macrophage colony stimulating factor (GM-CSF). In neutrophil monolayer assays, pre-treatment of cells with ultrapure GM-CSF at 40 Units ml-1 for a minimum of 1 h showed a significant enhancement of phagocytosis of Candida albicans (phagocytic index of 26 compared with 16 for unactivated neutrophils) after a 20 min ingestion period (P < 0001). By counting viable colonies 50% of intracellular yeast cells were killed by nonactivated neutrophils following internalization for 2 h. Neutrophils activated for 2 h with 40 Units ml-1 of GM-CSF killed 90% of intracellular blastoconidia (P < 002). These results demonstrate that in in vitro assays GM-CSF enhances phagocytosis and intracellular killing of C. albicans."

 

Full Article:

http://www.informaworld.com/smpp/content~db=all~content=a778682335?words=candida*%7Calbicans




Keywords: phagocytosis Candida albicans GM-CSF neutrophils

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