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Anthrax-Protective Effects of Yeast Beta1,3 Glucans

Anthrax-Protective Effects of Yeast Beta1,3 Glucans

Bill Kournikakis, PhD, Rosemonde Mandeville, MD, PhD, Pauline Brousseau, PhD, Gary Ostroff, PhD


"The anti-infective mechanism of action of beta1,3-glucan is mediated via the stimulation of the microbicidal activity of circulating blood cells (mainly monocytes/macrophages/dendritic cells, neutrophils, and natural killer cells) of the innate immune system. This involves interactions with a series of protein and glycolipid receptors present on the membranes of phagocytic white blood cells. Upon beta1,3-glucan binding, these receptors become crosslinked, initiating a selective cascade of cellular responses. This response also includes the proliferation of white blood cells in the bone marrow, leading to higher levels of these cells in the body, and an increased immune functionality of these cells. The documented increase in immune functionality includes increased ability of immune cells in circulation to recognize and migrate to a distal site of pathogenic challenge, increased phagocytic capacity, and increased production of endogenous antimicrobial agents, such as reactive oxygen intermediates, leading to an enhanced ability of the immune system to resolve a pathogenic challenge."


Full Article:

http://www.medscape.com/viewarticle/450700_4






Keywords: Anthrax Protective Effects Yeast Beta1 3 Glucans microbicidal activity monocytes macrophages dendritic cells neutrophils

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