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Immunological Features In Chronic Granulomatous Candidiasis

IMMUNOLOGICAL FEATURES IN CHRONIC GRANULOMATOUS CANDIDIASIS

H. VALDIMARSSON, C. B. S. WOOD, J. R. HOBBS AND P. J. L. HOLT


"Immunological phenomena associated with chronic mucocutaneous candidiasis have recently been intensively studied by many workers (reviewed by Kirkpatrick, Rich & Bennett, 1971). The results have shown that there is no common immunological denominator in this disease. The most common finding, however, is defective cellular immunity, which may or may not be accompanied by failure of in vitro lymphocyte transformation."


A boy aged 6 years with severe chronic mucocutaneous candidiasis of the granu-
lomatous variety has been treated with the dialysable transfer factor. Before the
treatment he was unable to express delayed hypersensitivity. His lymphocytes were
able, however, to produce migration inhibitory factor following in vitro challenge
with soluble candida antigens, but this activation was not accompanied by a signi-
ficant increase in DNA synthesis.
The treatment resulted in a temporary clinical improvement and return to
normal of his immune responses. After a relapse he was, 6 months later, once more
injected with transfer factor, which again proved effective.
Evidence is presented which suggests a defect of monocyte-macrophage function
in this patient and the pathogenesis of candida granulomata is discussed. It is
postulated that an amplifying mechanism involving lymphocyte-macrophage inter-
action is required for the normal expression of delayed hypersensitivity reactions
and the effective elimination of Candida albicans.


Full Article:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1553624/pdf/clinexpimmunol00295-0003.pdf


Keywords: IMMUNOLOGICAL FEATURES GRANULOMATOUS CANDIDIASIS phenomena mucocutaneous drjefftop advanced

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