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Undecylenic Acid Monograph

Undecylenic acid Monograph
Thorne Research, Inc.

"Relatively small doses of undecylenic acid and its salts have been shown to have powerful antifungal properties, and the dosages necessary to achieve therapeutic benefit appear to be safe. Undecylenic acid has been shown to be approximately six times more effective as an antifungal than caprylic acid, and is effective in maintaining a healthy balance of intestinal and vaginal flora."

Introduction

Most organic fatty acids are fungicidal and have been used for centuries as antimicrobial agents,
originally in the manufacture of soaps. In the last 50 years, however, they have found use both in vitro as
yeast and mold inhibitors in food stuffs, and as topical and systemic antifungals. Undecylenic acid (10-
undecenoic acid) is an eleven-carbon monounsaturated fatty acid, C 11H20O2. A substance
found naturally in the body (occurring in sweat), undecylenic acid is produced commercially by the
vacuum distillation of castor bean oil, via the pyrolysis of ricinoleic acid. It is an economical
antifungal agent and is the active ingredient in many topical over-the-counter antifungal preparations.1 Undecylenic acid has been shown to be approximately six times more effective as an antifungal than caprylic acid, and is effective in maintaining a healthy balance of intestinal and vaginal flora.

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Keywords: undecylenic undecenoic acid antifungal natural vaginal infection intestinal flora caprylic acid topical castorl bean oil

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