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Mechanisms by Which Antibiotics Increase the Incidence and Severity of Candidiasis and Alter the Immunological Defenses

"Patients on antibiotics experience proliferation of Candida albicans in the alimentary canal. This report presents evidence that the antibiotics enhance the invasiveness of the C. albicans, not only by a direct effect on the intestinal flora, and on the Candida itself, but also by depressing the host defense mechanisms."

MILDRED S. SEELIG, Department of Plharmacology, New York Medical College, Flower and Fifth Avenue Hospitals, and Squibb International

Substantial clinical evidence has been accumu-
lated, showing that candidiasis is a medical
problem of increasing magnitude. That pa-
tients on antibiotics experience proliferation of
Candida albicans in the alimentary canal is no
longer a point for dispute. That the increased
incidence of severe fungus infections is associated
with antibiotic therapy, particularly in patients
with subnormal defense mechanisms, is being
increasingly accepted. A recent report has presented
an analysis of published experimental and clinical
data which indicate that the two clinically disparate conditions-the
ostensibly benign proliferation of C. albicans,
and the invasion and spread of the organism in
debilitated patients-are interrelated. This re-
port presents evidence that the antibiotics en-
hance the invasiveness of the C. albicans, not
only by a direct effect on the intestinal flora,
and on the Candida itself, but also by depressing
the host defense mechanisms.

Full study http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=441005&blobtype=pdf





Keywords: candidiasis antibiotics Candida albicans fungus infections C. albicans defense mechanisms advanced

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